PhD Scientific Days 2018

Budapest, April 19–20, 2018

Gender differences on the adatptation of coronary resistance arteries in sport

Török, Marianna

Marianna Török1, Anna Monori-Kiss2, Éva Pál2, Eszter Horváth1, Attila Jósvai3, Petra Merkely1, Alex Ali Sayour4, Csaba Mátyás4, Attila Oláh4, Tamás Radovits4, Béla Merkely4, Nándor Ács1, György L. Nádasy5, Szabolcs Várbíró1

1. 2nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest
2. Institute of Clinical Experimental Research, Semmelweis University, Budapest
3. Department of Neurosurgery, Military Hospital, Budapest
4. Heart and Vascular Center, Semmelweis University, Budapest
5. Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest

Language of the presentation

Hungarian

Text of the abstract

Introduction: Remodeling of the heart caused by sustained, intense physical exercises is known for a long time. The increased muscle mass would need an increased perfusion which would require the remodeling of the coronary circulation, but coronary arterioles adaptation and influence of the genders in this process is unclear. Aims: Our aim was to evaluate the development characterstics of coronary arterioles adaptation and gender differences during long-term training. Method: Rats were divided into trained male and female (MTr and FTr) and control male and female (MCo and FCo) groups, with 8 rats in each group. Trained rats swam 200 min/day for 12 weeks. Ventricular function was checked by echocardiography. After 12 week-long training, intramural coronary resistance arteries were removed for pressure arteriography. Contractility (spontaneous and TxA2 agonist induced tones), endothelial and non-endothelial dilatation, tangential wall stress and elastic modulus were examined. Elastica remodeling was investigated stained by resorcin-fuchsin on histological sections. Results: Relative heart mass increased both in trained male and female animals along with elevated ejection fraction and fraction shortening. Coronary resistance arteries had elevated ratio of wall thickness to lumen diameter and increased elastic moduli at 15-30 kPa in MTr and FTr rats. The endothelial and non-endothelial relaxations became more effective in trained male rats. Both spontaneous and TxA2 agonist-induced tone increased in FTr rats. In trained female rats the inner elastic membrane’s distance from endothelial surface increased, while in trained male animals the thickness increased compare the control groups. Conclusion: While in swimmer female animals we measured stronger contraction, the endothelial and non-endothelial relaxations improved more in the swimmer male animals. The range of coronary vascular reactivity increased in both genders, but its mechanism was different males and females. Support: NKFIH K120277, STIA-KF-17.

Data of the presenter

Doctoral School: Clinical Medicine
Program: Molecular Genetics, Pathomechanism and Clinical Aspects of Metabolic Disorders
Supervisor: Szabolcs Várbíró
E-mail address: torok.marianna91@gmail.com