Andrea Edit Edes1,2, Gyongyi Kokonyei1,3, Attila Galambos1,3,4, Natalia Kocsel1,3,4, Edina Szabo1,3,4, Dorottya Pap2, Lajos R. Kozak5, Gyorgy Bagdy2,6, Gabriella Juhasz1,2
1 SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest
2 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest
3 Institute of Psychology, Eötvös Loránd University, Budapest
4 Doctoral School of Psychology, Eötvös Loránd University, Budapest
5 MR Research Center, Semmelweis University, Budapest
6 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, S Semmelweis University, Budapest
Rumination, i.e. the repetitive thinking about distress-related events, is an important risk factor in the development and maintenance of mental disorders, such as depression and anxiety, and is also related to the pathomechanism of chronic pain syndromes and migraine.
The aim of our study was to investigate rumination-related brain activation changes to pain with functional MRI (fMRI).
In the present study, we examined the brain activation changes with BOLD (blood oxygen level dependent) fMRI during perception of pain in 30 healthy subjects (18 women, mean age ± SD: 25.97 ± 4.04 years). For this reason, we used electric stimuli on the right hand of the participants, characterized by painful (VAS=7) and non-painful (VAS=3). All electric stimuli (n=30) were preceded by a visual cue, either pain cue or no pain cue. We assessed trait rumination with the 10-item Ruminative Response Scale (RRS).
Increased brain activation in several brain areas correlated positively with rumination scores regardless of preceding cues. Some of these areas are important parts of the pain processing network and therefore this phenomenon may be related to chronic pain states or migraine.
Our results suggest that highly ruminative individuals have an increased neural response to pain. In addition, this observation highlights the impact of cognitive psychotherapeutic approaches in managing pain syndromes and migraine.
The study was supported by the Hungarian Brain Research Program (Grant No. KTIA_NAP_13-2-2015-0001, 2017-1.2.1-NKP-2017-00002) and the Hungarian Academy of Sciences (MTA-SE Neuropsychopharmacology and Neurochemistry Research Group). Andrea Edit Edes was supported by the ÚNKP-17-3-IV-SE-3 New National Excellence Program Of The Ministry Of Human Capacities. LRK was supported by the Bolyai Research Fellowship.
Doctoral School: Doctoral School of Mental Health Sciences
Supervisor: Gabriella Juhász
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