PhD Scientific Days 2018

Budapest, April 19–20, 2018

Effect of orally administrated probiotics on Porphyromonas gingivalis in oral cavity: review and meta-analysis

Thanyaporn, Sang-ngoen

Sang-ngoen Thanyaporn
Department of Oral Biology, Semmelweis University, Budapest, Hungary

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Text of the abstract

Introduction: The success of using probiotics for management of intestinal tract problems attracted the attention of several researchers to study other possible effects of them, such as promoting oral health by preventing and treating oral infections including dental caries and periodontal disease. The presently available systematic reviews and meta-analyses studying the effect of probiotics focused on the clinical improvement of the periodontium. However, Porphyromonas gingivalis is regarded to be a key factor of dysbiosis in the biofilm leading to periodontitis. Therefore, the quantity of Porphyromonas gingivalis and other periodontopathogenic bacteria in saliva, supra- or subgingival plaque could be reliable monitoring factors in periodontal disease.

Aims: We aimed to collect data of clinical trials and statistically analyze the effects of orally administered probiotics on Porphyromonas gingivalis and other periodontopathogenic bacteria in saliva, supra- and subgingival plaque.

Method: An electronic search was conducted on 28 February 2018 in PubMed, Cochrane Library and Embase. Human studies, written in English, comparing a probiotic product with a placebo or no probiotics treatments were included. The effect of probiotics was investigated on the quantity of Porphyromonas gingivalis and other periodontopathogenic bacteria found in saliva, supra- and subgingival plaque.

Results: Using meta-analysis algorithms only two randomized clinical trials could be found. These articles uniformly revealed the significant reduction of Porphyromonas gingivalis in patient group treated with Lactobacillus reuteri tablets compared to control group. However, one study indicated no significant change in the other periodontopathogenic bacteria number while another study illustrated significant reduction of periodontopathogenic bacteria after 4 weeks probiotics administration. All other probiotic studies remained unparalleled, or not meeting the criteria of being randomized clinical trial.

Conclusion: The originally planned meta-analysis cannot be conducted because of the shortage of data. However, according to the available studies, Lactobacillus reuteri may be beneficial to gingivitis and periodontitis patients.

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Doctoral School: Clincal Medicine
Program: Dental Research
Supervisor: Gábor Varga
E-mail address:
oral presentation