Arianna Dégi1, Adrienn Bárczi1, Éva Kis2, Orsolya Cseprekál3, Ádám György Szabó4,
Gábor Rudas4, György S Reusz1
1 Semmelweis University, 1st Department of Pediatrics, Budapest
2 Gottsegen György Hungarian Institute of Cardiology, Budapest
3 Department of Transplantation and Surgery of Semmelweis University, Budapest
4 Semmelweis University, MR Research Center, Budapest
Standard pulse wave velocity (PWV) determination requires the measurement of the pulse wave transit time and the distance of the measurement sites. In adults the formula 0.8xsurface distance (L0.8)) is used based on MRI validation. Normative values do exist for PWV in children using the substracted method (LSM) There are no imaging validation studies in the developing paediatric population.
Our aim was to compare site distances determined by MRI and by surface measurements in pediatric patients.
21 patients were included (3.2-17.8 years, 16 males). The MRI measurements were part of the routine check-up. Before MRI PWV measurement was performed, and the pulse wave travel distance was assessed by surface tape measurements (L0.8 and LSM). Carotid, femoral and additional sampling sites were measured and labelled by MRI detectable vitamine A capsule. MRI images were analysed by Philips Extended MR WorkSpace 22.214.171.124 software. To calculate the reference distance (LREF) for the real travelled aortic path length, centerpoints were put manually in each slice and a centreline was reconstructed. Bland Altman plots (BA) were contstructed to assess the difference between the distances.
There was high correlation (r>0.86, p<0.00001) between surface and MRI distance measurements. According to L0.8 and LREF the average difference was 35.9 cm ( 8.7%) and BA plots showed significant difference. The difference between LSM and LREF was 2 cm (0.5%) and in the BA analysis there was a good accordance between LSM and LREF. In patients >13 years there was a proportional error in the BA plots.
In our study group the path assessed by the substracted method showed excellent correlation with intraarterial MRI measurements. The small number of cases does not allow to conclude on the difference in postpubertal patients, that needs further evaluation.
„Supported BY the ÚNKP-17-3 New National Excellence Program of the Ministry of Human Capacities”
Doctoral School: Clinical Medicine
Program: 03. Prevention of Chronic Diseases in Childhood
Supervisor: György S Reusz
E-mail address: firstname.lastname@example.org