PhD Scientific Days 2019

Budapest, April 25–26, 2019

Citalopram elicited acute changes in anterior cingulate functional connectivity are associated with trait anxiety

Édes, Andrea

Andrea Edit Edes 1,2, Xenia Gonda 3,4, Kinga Gecse1,2, Gyorgy Bagdy 2,4, Gabriella Juhasz 1,2,6

1 SE-NAP2 Genetic Brain Imaging Migraine Research Group, Semmelweis University, Budapest, Hungary
2 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary
3 Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
4 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary
5 Division of Neuroscience and Experimental Psychology, The University of Manchester and Manchester Academic Health Sciences Centre, Manchester, United Kingdom

Language of the presentation

Hungarian

Text of the abstract

Introduction:
During the last decades the neuroimaging studies on serotonergic neurotransmission showed that selective serotonin reuptake inhibitor (SSRI) drug challenges can cause widespread resting functional connectivity changes in healthy brain. Functions of serotonergic system are also related to a significant risk factor to mental disorders, trait anxiety.

Aims:
As the anterior cingulate cortex (ACC) is a key hub of the default mode network (DMN), in this study we investigated the association between the connectivity changes of ACC to iv. citalopram and trait anxiety.

Method:
33 healthy individuals from both gender participated in a 30 minutes long functional MRI session in resting state. 7.5 mg citalopram administration to all participant was performed over 7.5 minutes after a 10 minutes long baseline period. The 10 minutes baseline and the last 10 minutes of the session were compared in the ACC seed-to-voxel analyses. The functional connectivity analyses was performed with CONN toolbox v18 for SPM. We measured trait anxiety with the State-Trait Anxiety Inventory (STAI-Trait). The effects of age and sex were controlled in the analyses.

Results:
We found decreased functional connectivity between the ACC seed region and in four clusters to intravenous citalopram in association to trait anxiety. These clusters involved the precentral gyrus, the middle cingulate gyrus (MCG), the caudate and the supplementary motor cortex.

Conclusion:
Our results suggest that the immediate changes in brain functional connectivity to SSRI drug treatment may be related to the trait anxiety. As the ACC is not only part of the DMN but also the salience network, changes in nonconscious attentional processes might be related to this phenomenon.

Funding: The study was supported by KTIA_NAP_13-2-2015-0001; 2017-1.2.1-NKP-2017-00002; Bolyai Research Fellowship Program; ÚNKP-18-4-SE-33 and ÚNKP-18-3-III-SE-6 New National Excellence Program.

Data of the presenter

Doctoral school: Doctoral School of Mental Health Sciences
Program: Psychiatry
Supervisor: Gabriella Juhász MD PhD
e-mail address: edes.andrea88@gmail.com