PhD Scientific Days 2019

Budapest, April 25–26, 2019

RETROSPECTIVE BLOOD PRESSURE PROFILE IN PEDIATRIC KIDNEY TRANSPLANT RECIPIENTS

Berta, László

Berta László1, Bárczi Adrienn1, Reusz György1, Kelen Kata1, Pethő-Orosz Petronella1, Sallay Péter1 Szabó Attila1,2

1 I. Department of Pediatrics, Budapest1
2 MTA-SE Pediatric and Nephrology Research Group, Budapest2

Language of the presentation

Hungarian

Text of the abstract

Introduction:
Cardiovascular risk plays a major role in the long term mortality and morbidity, in pediatric kidney transplantation (KT) and should be monitorized well. However serious CV events are rare in children, early signs of pathological processes are important in the long-term survival. 24-Hour Ambulatory Blood Pressure Monitoring (ABPM) is the gold standard in blood pressure (BP) profiling.

Aims:
The main purpose of the study was to describe the BP profiles and changes, 5 and 10 years after KT.

Methods:
86 pediatric kidney recipients (mean age: 11,26 (± 3,95 years; 52 males) were retrospectively analysed. We investigated 110 ABPM measurements 1,02 (± 0,65) years (Timepoint A), 5,05 (± 1,05) years (Timepoint B) and 10,41 (± 1,78) years (Timepoint C) after transplantation. We also collected casual blood pressure (CBP) measurements, demographic-, anthropometric-, donor-, complications-, medication informations and outcomes.

Results:
14 rejections and 1 exitus occured, 4 out of them in our timerange. Mean 24-hour BP were A: 86,24 ± 8,65 Hgmm B: 86,75 ± 10,12 Hgmm C: 87,88 ± 7,94 Hgmm. Non-dippers and reverse-dippers (n) were A: 24 and 8 (76,2%), B: 29-6 (66,04%), C: 20-5 (78,13%). Normal tension was observed in incresing numbers over the years. White coat hipertension (HT) was observed significantly higher earlier after Tx. Masked HT decreased over time and sustained HT were stagnated. Controlled HT increased and non controlled HT decreased during 10 years.

Conclusion:
BP profile did not considerably change during the 10 year timerange, although more and more patient had controlled HT with medication. BP-dipping stagnated over time and it’s role as a risk factor may need further evaluation in our study. However, white coat HT was remarkably high at timepoint A, but decreased over time.

Supported by the ÚNKP-18-3-I New National Excellence Program of the Ministry of Human Capacities.

Data of the presenter

Doctoral School: Clinical Medicine
Program: Prevention of chronic diseases in childhood
Supervisor: Attila Szabó
E-mail address: berta.laszlo@med.semmelweis-univ.hu