PhD Scientific Days 2021

CL_I_P: Clinical Medicine I. Posters

Age- and Sex-specific Reference Values of Right Ventricular Compacted and Trabeculated Myocardium by Cardiac Magnetic Resonance

Text of the abstract

Aims: The threshold-based trabecular quantification method for cardiac magnetic resonance (CMR) postprocessing analysis makes it possible to precisely quantify both compacted (RV-CMi) and trabeculated (RV-TMi) myocardial masses. We aimed to describe the age- and sex-related normal reference values of the RV-CMi, the RV-TMi and RV volumetric and functional parameters and investigate the determinants of RV myocardial mass value with CMR.
Methods: Two hundred healthy Caucasian volunteers free of known cardiovascular or systemic diseases were enrolled in this study. Four different age groups were established with equal numbers of males and females: Group A (n=50, 20-29 years), Group B (n=50, 30-39 years), Group C (n=50, 40-49 years), and Group D (n=50, ≥ 50 years). RV volumetric and functional, RV-CMi and RV-TMi values were measured with a threshold-based postprocessing method for CMR.
Results: The age- and sex-related normal reference ranges of the RV-CMi and the RV-TMi and RV volumetric and functional parameters were established. The volumetric parameters RV-CMi and RV-TMi were larger in males, and the ejection fraction (EF) was higher in females. The RV-CMi remained unchanged over time in both sexes, and the RV-TMi decreased with age in females and remained stable in males. The RV-TMi and RV-CMi correlated positively with RV volumetric parameters, the left ventricular (LV)-CMi, the LV-TMi and each other in both sexes. Sex, LV-TMi, LV-CMi and RV end-systolic volume were independent predictors of RV-TMi.
Conclusion: The use of RV-trabeculated and RV-compacted myocardial mass normal values might have additive value in diagnosing different conditions with RV hypertrophy or hypertrabeculation.
Funding: EFOP-3.6.3-VEKOP-16-2017-00009

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine