PhD Scientific Days 2022

Clinical Medicine VII. (Poster discussion will take place in the Aula during the Coffee Break)

Characteristics of the Right Ventricle in Left Ventricular Noncompaction with Reduced Ejection Fraction

Text of the abstract

Reports of left ventricular noncompaction (LVNC) rarely include descriptions of the right ventricle (RV).
This study aimed to describe the characteristics of the RV in LVNC patients with reduced LV function (LVNC-R) compared with patients with dilated cardiomyopathy (DCM) and subjects with LVNC with normal left ventricular ejection fraction (LV-EF) (LVNC-N).
Forty-four LVNC-R patients, 44 LVNC-N participants, and 31 DCM patients were included in this retrospective study (LV-EF: LVNC-R: 33.4±10.2%; LVNC-N: 65.0±5.9%; DCM: 34.6±7.9%). Each group was further divided into two subgroups by the amount of RV trabeculation.
There was no difference in the RV-EF between the groups, and the RV trabecular mass correlated positively with the RV volume and negatively with the RV-EF in all the groups. All the measured parameters were comparable between the groups with decreased LV function. Subgroups with RV hypertrabeculation showed significantly higher RV volumes and lower RV-EF in the decreased-LV-function groups than patients with normal RV trabeculation. LV trabeculation correlated with RV volumes in both noncompacted groups, while the correlation with RV trabeculation was observed only in the LVNC-N group (r=0.469, p=0.001). Both decreased-LV-function groups had worse RV strain values than the LVNC-N group; however, RV strain values correlated with RV trabeculation predominantly in the LVNC-R group.
Correlations between LV trabeculation and RV parameters and the presence and characteristics of RV hypertrabeculation raise the possibility of RV involvement in noncompaction; moreover, RV strain values might be helpful in the detection of early subclinical changes of the RV.

Fundings:
Thematic Excellence Programme (Tématerületi Kiválósági Program, 2020-4.1.1.-TKP2020) of the Ministry for Innovation and Technology in Hungary within the framework of the Therapeutic Development and Bioimaging Programs of Semmelweis University.
Development of Scientific Workshops of Medical, Health Sciences and Pharmaceutical Education (Project identification number: EFOP-3.6.3-VEKOP-16-2017-00009).
Ministry of Innovation and Technology NRDI Office within the framework of the Artificial Intelligence National Laboratory Program (Project no. NVKP_16-1–2016-0017).