PhD Scientific Days 2022

Clinical Medicine VIII.

Kidney biopsy-based epidemiologic analysis shows growing biopsy rate among the elderly

Text of the abstract

Introduction
Epidemiologic trends on the prevalence of renal diseases are available throughout Europe. Hungary lags in the assessment of the temporal trends and changing patterns of kidney biopsies based on clinicopathological data.

Methods
We analyzed native biopsy samples processed at the 2nd Department of Pathology, Semmelweis University between 2006- 2020. Diagnoses were standardized according to the European Renal Association-European Dialysis and Transplant Association coding system. Chi-square and Fisher’s exact and Kruskal-Wallis test were used. We analyzed binary dependent variables with logistic regression.

Results
We evaluated 2140 biopsies, 2296 diagnoses. The number of samples increased from 24.5 to 57.9 per million person-year and the median age from 37 to 51 years (p<0.0001). The predominance of glomerular diseases was stable. The most frequent diagnosis was IgA nephropathy (IgAN) (21.5%). Hypertension/renal vascular diseases (HT/RV) (p=0.009), FSGS (p=0.027) and minimal change disease (p=0.038) decreased. ANCA-associated vasculitis (p=0.004) and MPGN increased (p=0.021). There was a higher number of males in diabetes mellitus (DM) (p=0.025), membranous nephropathy (MN) (p=0.022) IgAN (p<0.0001), more females in the FHN (p=0.038), MPA (p<0.0001), lupus nephritis (p<0.0001) and amyloidosis (p=0.008) groups. DM (p<0.0001), HT/RV (p<0.0001), MN(p<0.0001), MPA (p<0.001), and EGPA (p=0.017) were more frequent in adults/elderly. MCD (p<0.0001), FSGS (p=0.001), and IgAN (p<0.0001) were the most prevalent in children. COVID pandemic decreased the frequency of MN (p=0.021).

Conclusion
Biopsy rate increases among the elderly and there is a growing frequency of age-related diseases, which emphasize the importance of altering medical focus according to demographic changes in this area.

Funding
Not applicable