PhD Scientific Days 2022

Clinical Medicine V. (Poster discussion will take place in the Aula during the Coffee Break)

Comparison of imaging modalities for left ventricular noncompaction patients

Text of the abstract

Out of 2D and 3D echocardiography (2DUS, 3DUS) and cardiac MR (CMR), it is not decided which is better for follow-up of left ventricular noncompaction (LVNC) patients. Thus, we aimed to assess the correlation (C) and agreement (A) between CMR, 2DUS, and 3DUS by comparing the volumetric and strain parameters in a hypertrabeculated and a healthy population.
Thirty-eight LVNC patients (male: 25; average age: 36±13 years) with good left ventricular ejection fraction (EF) without any comorbidities and 34 healthy (H) subjects (male: 19; average age: 31±14 years) were enrolled in our study. A pairwise comparison was performed among the three modalities.
There was good correlation and agreement in the healthy group for volumetric data, except for end-systolic volume (ESV) in the 2DUS-CMR (C: r= 0.21, p= 0.19; A: PE= 70%, p: 0.06) comparison. However, with acceptable correlation only less agreement was found in the LVNC group, namely, in 2DUS-3DUS end-diastolic volume (C: r= 0.73, p<0.001; A: PE= 28.9%, p= 0.04), in 2DUS-CMR stroke volume (SV; C: r= 0.54, p<0.001; A: PE= 29%, p<0.001) and in 3DUS-CMR SV (C: r=0.75, p< 0.001; A: PE= 25%, p <0.001). Functional parameters (EF and global strains) in the healthy group showed good agreement but no correlation; in the LVNC group, none of the functional parameters were correlated and were mostly not in agreement.
In this study found good agreement between modalities in the healthy group; however, hypertrabecularization may result in inaccuracy by comparing modalities, especially when evaluating strain parameters.