PhD Scientific Days 2022

Clinical Medicine VII. (Poster discussion will take place in the Aula during the Coffee Break)

Investigating the effect of phototherapy and tanning bed usage on serum vitamin D levels

Text of the abstract

Introduction
Vitamin D deficiency is a public health disease that can be associated with a number of diseases. Vitamin D provitamin is formed in the skin by UV radiation, which acquires its active form after double hydroxylation. Instead of the recommended oral supplementation, many people use excessive sun exposure or artificial UV sources, which pose an oncodermatological risk. The literature data on the effects of dermatological phototherapy and tanning use on vitamin D levels are contradictory.
Aims
Our aim was to study the mentioned therapeutic procedures and the effects of the solarium on vitamin D and folic acid levels, as well as to assess the vitamin levels of the studied population.
Methods
Four groups were examined: 1. group of patients treated with NBUVB (n = 20), 2. group of patients treated with PUVA (n = 10), 3. healthy group using solarium (n = 15), 4. oral 3000NE / die D -vitamin group (n = 20) and 5 healthy control groups (n = 15). 1-2. groups of 15 suitable phototherapeutic treatments were completed with a dose series appropriate to the skin type. Group 3 used a tanning bed 15 times with standardized doses. Subjects' vitamin D and folic acid levels were measured before, during, and after the treatment series. Results were evaluated by a two-way ANOVA statistical test.
Results
In our study, we confirmed baseline vitamin D levels below the normal range in all groups, with folic acid levels in the normal range. In groups 1, 3, and 4, a significant increase in vitamin D was observed, while in group 2, the value did not increase significantly. The vitamin D levels ​​of group 5 did not change. No significant decrease in folic acid levels was found as a result of the treatments.
Conclusion
Based on its results, it can be concluded that vitamin D deficiency can be achieved in both the patient and healthy groups we studied. In addition to oral supplementation, vitamin D levels are also significantly increased by NBUVB treatment and solarium use. There is currently no evidence of such a link with the NBUVB. As the latter did not substantially reduce folic acid levels, its use for a specified period of time and at a dose can be considered safe and effective in raising vitamin D levels.