PhD Scientific Days 2022

Pharmaceutical Sciences II. (Poster discussion will take place in the Aula during the Coffee Break)

Amid bond formation in continuous flow system

Text of the abstract

Introduction:
My research activity is around flow chemical reactions. In flow chemistry, a chemical reaction is run in a continuously flow system. Continuous flow reactions are green synthetic reactions, because of compared to batch reactions, the flow reactions are: safer; the reaction control is more precise; the reaction is more selective and easy to repeat; there is no room for the formation of unstable intermediates. A further advantage of flow chemical reactions is that the reaction conditions (temperature, pressure, flow rate) can be changed dynamically and accurately. Also, these reactions generally have a higher yield percentage and are more economical than the conventional batch process.
Background:
The direct amidation in several ways a very significant reaction. It also has biological and chemical significance, for example forms a protein binding.
Aims:
We aimed to create an efficient and green chemical formation of an amide bond. Best suited for this is flow chemical technology.
Method:
We worked with a continuous flow chemical reactor. The reactor is made up of an hplc pump, a manual simple injector, a stainless steel loop in a thermostat, and pressure regulator. Reactions were performed with tetramethyl orthosilicate catalyst with various solvents.
Results:
After optimizing the reaction conditions, I achieved a yield of 80%.
Conclusion:
The formation of the amide bond by flow chemistry appears to be better yielded, more economical, without by-products, greener than the conventional method.