PhD Scientific Days 2026

Poster Session 3.L - Health Sciences

Mapping global research on real-world evidence in Oncology care pathways

Name of the presenter

Nguyen, Thi Phuong Thao

Institute/workplace of the presenter

Center for Health Technology Assessment

Authors

Thao T P Nguyen^1,2, Saruultuya Nergui³, Le Duc Huy⁴, Doan Minh Nhat Vo^2,5, Balazs Nagy¹, Voko Zoltan¹
1: Center for Health Technology Assessment, Semmelweis University, Hungary
2: Hue University of Medicine and Pharmacy, Hue University, Vietnam
3: Bayangol Health Center, Mongolia
4: Vanderbilt University, The United State
5: Center for Translational Medicine, Semmelweis University, Hungary

Text of the abstract

Introduction: Real-world evidence (RWE) has become increasingly important in supporting cancer care pathways, yet its global development patterns remain unclear. This review aims to systematically identify and map the status of research on RWE applications in oncology care pathways from 2010 to 2024.
Methods: We followed the PRISMA-Scr methodology and conducted a bibliometric analysis by using Web of Science and Scopus. All peer-reviewed English-language publications published between 2010 and 2024 were included after conducting keyword searches on “oncology/cancer”, “treatment sequences/ care pathways”, and “real-world evidence/ real-world data”. We used the Bibliometrix R package, EndNote, Rayyan, and Microsoft Excel to analyze and visualize the bibliometric parameters.
Results & Discussions: A total of 3,387 articles were retrieved from our search. After removing duplicates, title and abstract screening retained 1,678 articles. Most documents are original research articles (1,458), complemented by 132 reviews and a small number of clinical trials or observational studies. The United States, the United Kingdom, and Germany were the leading contributors. Concerning hot topics, from a tiny, surgery/chemotherapy-dominated field in 2010, the 2020-2024 transition represents oncology's maturation from a fragmented, therapy-siloed field to a holistic, interconnected ecosystem. By 2024, research is not just about discovering new drugs but synthesizing vast real-world datasets to optimize survival, minimize costs, and personalize immunotherapy, paving the way for future innovations like CAR-T expansions and AI-predictive models. RWE and metastatic breast cancer have replaced traditional chemotherapy as the central drivers of oncology research, while advanced non-small cell lung cancer and cellular immunotherapy are the fastest-emerging powerhouse topics of the near future.
Conclusion: This 15-year scoping review maps the dramatic RWE evolution of global oncology research. Future cancer care will only be truly precise when real-world evidence represents the entire real world.
Funding: This work was prepared with the professional support of the Ministry of Culture and Innovation’s University Research Scholarship Program in Hungary 2025-2.1.1-EKOP-2025-00014, financed from the National Research, Development and Innovation Fund.