PhD Scientific Days 2026

Dental Research

Periodontal status in cardiovascular patients

Name of the presenter

Nguyen, Quoc Duy

Institute/workplace of the presenter

Department of Restorative Dentistry and Endodontics

Authors

Nguyen Quoc Duy¹, Zsuzsanna Mihály², Péter Sótonyi², Elek Dinya³, Alexandra Kovács¹, Enikő V. Szabó¹, Zsolt M. Lohinai¹
1: Department of Restorative Dentistry and Endodontics, Semmelweis University
2: Department of Vascular Surgery, Heart and Vascular Center of Semmelweis University
3: Institute of Digital Health Science, Semmelweis University

Text of the abstract

Introduction: Over the past few decades, the role of oral pathogens in systemic disease has become focus of interest, particularly those involved in periodontitis. These pathogens have been implicated in the development of multiple systemic inflammatory conditions, including atherosclerosis. In patients with periodontitis, bacteria may migrate from inflamed sites into the bloodstream, potentially leading to systemic diseases. Numerous studies have demonstrated an association between periodontal pathogens and cardiovascular diseases. These bacteria have been identified in vascular lesions. The severity of periodontitis and its role in cardiovascular disease, however, has not been elaborated.
Aims: This study aims to investigate the periodontal status of patients undergoing vascular surgery, and to correlate the severity of periodontitis with carotid stenosis (CS) and aorta aneurysm (AA).
Methods: One hundred patients undergoing vascular surgery (50 with CS, 50 with AA) will be enrolled at Semmelweis University. Comprehensive periodontal examination and multi-site oral sampling are performed preoperatively for microbial and genetic susceptibility PCR analysis.
Preliminary result: Thirty patients have been enrolled so far, with 1 exclusion. Most patients show periodontal disease, with 1 classified as Stage IV, 11 as Stage III, 2 as Stage II and 5 being edentulous in the AA group and with 9 as Stage III and 1 edentulous in the CS group. Bleeding scores ranged from 3% to 79%, and plaque indices from 4% to 90%. Mann-Whitney U test showed significant correlation between cardiovascular disease and PPD≥5mm% score (p=0,00008), while tendency was found in regards with mean probing depth (p=0,08) and no correlation was seen with mean attachment level (p=0,18). There is no difference between the two groups in the cause of tooth loss (two-sided Fisher test; p=1,00). Microbial and genetic susceptibility analyses are ongoing.
Conclusion: Carotis stenosis patients have higher PPD≥5mm% score than aorta aneurysm patients indicating worse periodontal condition with a higher possibility for bacterial translocation.
Funding: Dental Faculty Grant 2026
- Email: duy.nguyen@phd.semmelweis.hu
- University: Semmelweis University
- Supervisors: Vasziné Enikő Szabó Ph.D., Prof. Zsolt Lohinai Ph.D. Med. Habil. *equally contributed