PhD Scientific Days 2026

Poster Session 3.L - Health Sciences

Effect of systematic training on vitamin levels in healthy population: a systematic review and meta-analysis

Name of the presenter

Barna, Viktória

Institute/workplace of the presenter

Department of Pharmacology and Pharmacotherapy/Centre for Translational Medicine

Authors

Viktória Barna^1,2,3,4, Fruzsina Szilágyi^1,2, Marie Anne Engh^1,2, Vivienne Seymour^1,2, Péter Hegyi^1,5,6, Csaba Kónya⁷, Renáta Papp^1,2,3, Tibor Hortobágyi^8,9,10, *Nora Sydo^1,11,12, *Péter Ferdinandy^1,2,2,4
1: Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
2: Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
3: Center for Pharmacology and Drug Research & Development, Semmelweis University, Budapest, Hungary
4: Pharmahungary Group, Szeged, Hungary
5: Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
6: Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary
7: Béres Pharmaceuticals Ltd, Budapest, Hungary
8: Hungarian University of Sports Science, Department of Kinesiology, Budapest, Hungary
9: Department of Human Movement Sciences, University of Groningen Medical Center, Groningen, The Netherlands
10: Faculty of Sport Science, Ningbo University, Ningbo, China
11: Heart and Vascular Center, Semmelweis University, Budapest, Hungary
12: Department of Sports Medicine, Semmelweis University

Text of the abstract

Introduction: Vitamin supplementation is often recommended for physically active individuals, but evidence is limited on how systematic training affects vitamin requirements in healthy, non-athlete adults. Aim: To investigate the effect of systematic training on vitamin levels in healthy individuals through a systematic review and meta-analysis. Methods: This meta-analysis included human randomized controlled trials assessing changes in plasma vitamin levels before and after systematic training interventions. Eligible participants were non-athletic healthy adults, with or without or supplementation during systematic training, respectively. Searches were conducted in PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases on February 20, 2025. Results: A total of 7318 records were identified, 5249 of which were screened, and 19 studies met the inclusion criteria. The overall analysis of Vitamin D levels of the trained group showed significantly higher Vitamin D level compared to untrained group (n= 628; MD = 3.03; 95% CI: 0.40 to 5.67; p = 0.027). α-tocopherol level was significantly higher in the trained group compared to untrained (n=148; MD = 1.67; 95% CI: 0.61 to 2.72.; p = 0.007). No significant differences were found for other vitamins with or without supplementation regardless of training type. Conclusion: Overall analysis of 19 studies demonstrates a significantly higher plasma Vitamin D and α-tocopherol levels due to systematic training in healthy adults compared to untrained. This may show that due to systematic training itself, there is no need for additional supplementation of Vitamin D and a-tocopherol beyond the dietary reference values in healthy adults. However, there is no sufficient data on the effect of training on other vitamin levels. Funding: This work was supported by the National Research, Development and Innovation Office of Hungary (Research Excellence Program TKP within the framework of the Therapeutic Development thematic program of Semmelweis University; National Heart Laboratory (RRF-2.3.1-21-2022-00003) by Semmelweis University (Semmelweis Lendület Grant; Translation Medicine Program), and by the 2024-2.1.2-EKÖP-KDP-2024-00002 University Research Scholarship Programme of the Ministry for Culture and Innovation from the source of the International Research Development and Innovation Fund.


Corresponding author
Péter Ferdinandy
Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
Center for Pharmacology and Drug Development, Semmelweis University, Budapest, Hungary
Pharmahungary Group, Szeged, Hungary

Correspondence
Péter Ferdinandy, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary. Email: peter.ferdinandy@pharmahungary.com

Viktória Barna: barna.viktoria2@semmelweis.hu
Engh Marie Anne: engh.marie@semmelweis.hu
Vivienne Seymour: vivienne.seymour@stud.semmelweis.hu
Péter Hegyi: hegyi2009@gmail.com
Papp Renáta Emese: papp.renata@semmelweis.hu
Nóra Sydó: sydo.nora@semmelweis.hu
Fruzsina Szilágyi: szilagyi.fruzsina99@stud.semmelweis.hu
Tibor Hortobágyi: t.hortobagyi@umcg.nl
Csaba Kónya: konya.csaba@beres.hu