PhD Scientific Days 2023

Budapest, 22-23 June 2023

Health Sciences I.

Ranking the effectiveness of 16 dietary fibre types on glycemic parameters in patients with type 2 diabetes

Anna Evelin Juhász1,4
Dorina Greff1,2,3
Brigitta Teutsch1,5
Noémi Gede5
Péter Hegyi1,5,6
Eszter Mária Horváth3
Pál Ákos Deák7
Péter Nyirády8
Nándor Ács2
Réka Juhász4

1Center for Translational Medicine, Semmelweis University, Budapest, Hungary
2Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
3Department of Physiology, Semmelweis University, Budapest, Hungary
4Department of Dietetics and Nutrition Sciences, Semmelweis University, Budapest, Hungary
5Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
6Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary
7Department of Interventional Radiology, Heart and Vascular Center, Faculty of Medicine, Semmelweis University, Budapest, Hungary
8Department of Urology, Semmelweis University, Budapest, Hungary

Text of the abstract

Diabetes mellitus is a major worldwide health problem, in which properly planned diet plays a keyrole. However, many patients have difficulties in keeping a low carbohydrate diet after diagnosis. Fibers are carbohydrate polymers, which are neither digested nor absorbed in the human small intestine. The findings from previous studies showed that the addition of dietary fiber could normalise blood glucose levels in patients with diabetes.
Several dietary fibers are available as a food supplement with various solubility, taste and physiological effect. To our konwledge no previous study has ranked their efficacy yet. Therefore we performed this systematic review and network meta-analysis to rank the effects of different types of soluble dietary fibers on glycemic in patients with type 2 diabetes.
We performed our systematic search on the 20th of November, 2022. Eligible randomized controlled trials (RCTs) included adult patients with T2DM; compared soluble dietary fiber intake with another type of dietary fiber or no fiber. The outcomes were related to glycemic levels. The Bayesian method was used to perform a network meta-analysis and to calculate the surface under the cumulative ranking curve (SUCRA) values to rank interventions. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was undertaken to evaluate the overall quality of the evidence.


We identified 46 RCTs, including data from 2685 patients receiving 16 types of dietary fibers as intervention. Galactomannan had the highest effect on reducing hemoglobin A1c (SUCRA 92.33%), and fasting blood glucose (SUCRA 85.12%). Regarding fasting insulin level and HOMA-IR, B glucan (SUCRA 73.45%) and psyllium (SUCRA 96.67%) were the most effective interventions. Moreover, galactomannan showed significant results in almost all outcomes compared to no fiber. Most comparisons had low or moderate certainty of evidence.


The most effecive dietary fiber was the galactomannan for reducing hemoglobin A1c and fasting blood glucose levels in patients with type 2 diabetes. Our results showed that supplemental fibers can influence metabolic parameters and using dietary fibers as a supplement besides the medical therapy is an effective way for managing type 2 diabetes.


None to declare.