PhD Scientific Days 2023

Budapest, 22-23 June 2023

Clinical Medicine - Posters A

Biventricular characteristics of left ventricular noncompaction using 3D echocardiography.

Márton Horváth1, Kristóf Farkas-Sütő1, Alexandra Fábián1, Bálint Lakatos1, Anna Réka Kiss1, Zsófia Gregor1, Balázs Mester1, Attila Kovács1, Béla Merkely1, Andrea Szűcs1

1 Heart and Vascular Center of Semmelweis University, Budapest

Text of the abstract

Previous studies conducted on the left ventricular noncompaction (LVNC) population have mainly used cardiac MR and 2D echocardiography (Echo) modalities and focused on the left ventricle. However, the right ventricular involvement of LVNC is less known, and no literature data were found on the issue using 3D Echo.

We aimed to compare left and right ventricular (RV) volumetric, functional and strain parameters of a LVNC and a healthy (HE) population using 3D Echo.

In our study we examined 3D Echo parameters of 41 LVNC subjects without any comorbidities and with good ejection fraction (EF>50%, 26 male, mean age 39±15 years) and compared them with an age and sex matched healthy population of 41 subjects (26 male, mean age 39±15 years). Endocardial contours were evaluated using the TOMTEC software to determine the following left and right ventricular parameters: end-diastolic and end-systolic volumes, stroke volume, ejection fraction, left ventricular global longitudinal and circumferential strain and right ventricular septal (SLS) and free wall longitudinal strain (FWLS). The results of the two groups were compared using the SPSS statistical program.

Although, compared to the HE population, the left ventricular volumetric parameters of the LVNC group were within the normal range but were significantly elevated, the right ventricular parameters did not differ significantly. The EF and strain values of the LVNC population were significantly decreased in both ventricles compared to healthy controls (RV: LVNC vs HE; EF: 54,0 ± 5,8% vs 58,8 ± 3,9%; SLS: -17,5 ± 4,2% vs -20,6 ± 3,2%; FWLS: -27,1 ± 5,7% vs -30,7 ± 4,7%).
In terms of clinical characteristics, the LVNC group had positive family history, arrhythmic complications and thromboembolic events 34.2%, 31.7% and 2.4% respectively.

Based on our 3D Echo study, subclinical right ventricular abnormalities may raise the possibility of right ventricular involvement in left ventricular noncompaction.