PhD Scientific Days 2023

Budapest, 22-23 June 2023

Clinical Medicine V.

Ineffectual Process Concerning the Initiation of Enteral Tube Feeding in Acute Pancreatitis. A Prospective, International, Multicenter Cohort Analysis of 1088 cases.

Inez Bosnyák1,2, Zoltán Sipos1,3, Noémi Gede1, Andrea Szentesi1, Áron Vincze1,4, Bálint Erőss1,2,5, Péter Hegyi1,2,5,6, Katalin Márta2,5

1Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
2Institute of Pancreatic Diseases, University of Semmelweis, Budapest, Hungary
3Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary
4Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary
5Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
6Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged, Szeged, Hungary

Text of the abstract

Introduction: Enteral feeding (EF) is recommended in the severe or predicted severe forms of acute pancreatitis (AP) to reduce mortality.

Aim: We aimed to investigate the factors leading to initiating EF in the acute phase (first three days of hospitalization) and the associations between EF and the disease outcome.

Methods: 1429 prospectively collected cases from 31 centers and 12 countries were included in the analysis. EF and Non-EF patient groups were formed concerning tube feeding in the first three days of the hospital stay. We investigated the associations between pancreatic and inflammatory laboratory parameters (amylase, lipase, CRP, WBC, LDH), imaging alterations (necrosis, fluid collections, etc.), and clinical symptoms influencing the initiation of EF (abdominal pain, vomiting, etc.). We used Fisher's exact test for categorical variables and the Mann-Whitney U test for not normally distributed continuous variables. A p-value <0.05 indicates a statistically significant difference.

Results: EF was applied during hospitalization in 30%, 41%, and 55% of mild, moderately severe, and severe cases, respectively. Significantly higher WBC (p=0.042 p=0.019, p=0.002 on D1, D2, and D3), CRP (p<0.001 on D3), and LDH (p=0.004, p=0.036 on D1 and D3) were detected in the EF group before nutritional support compared to the non-EF cases. The frequency of necrosis, pseudocyst, abdominal fluid collection (all with p<0.004), and the intensity of abdominal pain (p<0.001) were also significantly higher in the EF group before nutrition initiation. The overall mortality in this cohort was 2.8%. Notably, the mortality in the non-EF severe group was 10% higher than in the EF severe group (38% vs. 28%, p=0.384).

Conclusions: All parameters influencing the EF initiation here are not part of the current guidelines. In conclusion, decision-making mechanisms for initiating EF rely on personal preferences; therefore, there is still a substantial proportion of patients with severe AP without EF (45%). Since EF is cost-effective and has a very low complication rate if applied correctly, it should be introduced to all AP cases regardless of laboratory parameters and imaging findings.

Funding: This project was supported by the Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund (ITM-NRDIF) (TKP2021-EGA-23) and by the ÚNKP-22-4-II New National Excellence Program of the Ministry for Culture and Innovation from the Source of the National Research, Development and Innovation Fund (to KM).