PhD Scientific Days 2024

Budapest, 9-10 July 2024

Poster Session M - Cardiovascular Medicine and Research 1.

The effect of excessive trabeculation on cardiac rotation – a multimodal imaging study


Kinga Grebur1, Balázs Mester1, Márton Horváth1, Kristóf Farkas-Sütő1, Zsófia Gregor1, Anna Réka Kiss1, Attila Tóth1, Attila Kovács1, Alexandra Fábián1, Bálint Károly Lakatos1, Bálint András Fekete2, Csaba Bödör2, Katalin Csonka2, Béla Merkely1, Hajnalka Vágó1, Andrea Szűcs1
1: Semmelweis University, Heart and Vascular Center
2: Semmelweis University, Department of Pathology and Experimental Cancer Research

Text of the abstract

Cardiac rotational parameters in primary left ventricular noncompaction (LVNC) with preserved left ventricular ejection fraction (LVEF) are not well understood.
We aimed to analyze cardiac rotation measured with cardiac magnetic resonance feature-tracking (CMR-FT) and speckle-tracking echocardiography (Echo-ST) in LVNC morphology subjects with preserved LVEF and different genotypes and healthy controls.
Our retrospective study included 54 LVNC subjects with preserved LVEF and 54 control individuals. We evaluated functional and rotational parameters with CMR in the total study population and with echocardiography in 39 LVNC and 40 C individuals. All LVNC subjects were genotyped with a 174-gene next-generation sequencing panel and grouped into the subgroups: benign (B), variant of uncertain significance (VUS), and pathogenic (P).
In comparison with controls, LVNC subjects had reduced apical rotational degree and one-third had negative apical rotation. While the degree of apical rotation was comparable between the three genetic subgroups, they differed significantly in the direction of apical rotation. In contrast to control and B groups, all four studied cardiac rotational patterns were identified in the P and VUS subgroups, namely normal rotation, positive and negative rigid body rotation, and reverse rotation. When the CMR-FT and Echo-ST methods were compared, the direction and pattern of cardiac rotation had moderate to good association whereas the rotational degrees showed no reasonable correlation or agreement.
While measuring cardiac rotation using both CMR-FT and Echo-ST methods, subclinical mechanical differences were identified in subjects with LVNC phenotype and preserved LVEF, especially in cases with genetic involvement.
The research was supported by the ÚNKP-23-3-II new national excellence program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund; by the EFOP-3.6.3-VEKOP-16-2017-00009; by the TKP2021-NKTA-46 and by the TKP2021-NKTA funding scheme.