PhD Scientific Days 2025

Poster Session II. - L: Mental Health Sciences

Predictors of Well-Being and Functional Outcomes in Schizophrenia Spectrum Disorders: The Roles of Adherence, Discrimination, and Satisfaction with Care

Name of the presenter

Lisincki Anna Mária

Institute/workplace of the presenter

Semmelweis University, Department of Psychiatry and Psychotherapy

Authors

Anna Mária Lisincki¹, János Réthelyi¹, Éva Jekkel¹

1: Semmelweis University, Department of Psychiatry and Psychotherapy

Text of the abstract

Introduction
Quality of life and everyday functioning are crucial outcome domains in the care of individuals living with schizophrenia or schizoaffective disorder. However, the relationship between subjective well-being and objective functionality remains complex and is often influenced by treatment engagement and psychosocial factors.

Aims
This study explored how medication adherence, satisfaction with healthcare, and anticipated discrimination relate to both subjective and objective quality of life and functionality in patients diagnosed with schizophrenia spectrum disorders.

Method
Twenty-five patients meeting DSM-5 criteria for schizophrenia or schizoaffective disorder were recruited at Semmelweis University, Budapest. Participants were in remission and on stable pharmacotherapy. Clinical interviews and questionnaires assessed self-reported medication adherence (MMAS-8), anticipated discrimination (QUAD), satisfaction with care (CACHE), and quality of life (LQoLP, WHO-5).

Results
Higher medication adherence was strongly associated with improved objective functionality and clinician-rated well-being (rs = .661, p < .001), but not with subjective well-being. Adherence also correlated with greater satisfaction with healthcare (rs = .430, p = .032), which in turn was positively associated with subjective well-being (WHO-5: rs = .401, p = .047). Satisfaction with care significantly moderated the relationship between adherence and well-being (p = .010). Anticipated discrimination was weakly associated with reduced subjective well-being (rs = .400, p = .048).

Conclusion
Medication adherence and satisfaction with healthcare significantly contribute to patients’ functional outcomes and well-being. Addressing anticipated discrimination may further support recovery in schizophrenia spectrum disorders.

Funding
This study received no external financial support.