PhD Scientific Days 2025

Poster Session I. - T: Cardiovascular Medicine and Research

High prevalence of non-dipper and reverse dipper patterns among the Hungarian population according to the nationwide ABPM registry

Name of the presenter

Pásztor Dorottya Tímea

Institute/workplace of the presenter

South-Buda Center Hospital St. Imre University Teaching Hospital, The Doctoral College of Semmelweis University

Authors

Dr. Dorottya Tímea Pásztor¹, Dr. Johanna Takács, PhD², Dr. János Nemcsik, MD, PhD³, Zsófia Kekk³, Prof. Dr. Péter Torzsa, MD, PhD³, Prof. Dr. Dénes Páll, MD, PhD, DsC⁴, Prof. Dr. Ákos Koller, MD, PhD, DsC⁵, Prof. Dr. Zoltán Járai, MD, PhD⁶

1: South-Buda Center Hospital St. Imre University Teaching Hospital, The Doctoral College of Semmelweis University
2: Department of Social Sciences, Semmelweis University
3: Department of Family Medicine, Semmelweis University
4: Department of Medicine, University of Debrecen
5: Research Center for Sport Physiology, Hungarian University of Sports Science, Departments of Morphology & Physiology and Translational Medicine, Semmelweis University
6: South-Buda Center Hospital St. Imre University Teaching Hospital, Section of Angiology, Városmajor Heart and Vascular Center, Semmelweis University

Text of the abstract

Introduction: Current ESH guidelines recommend measuring night-time blood pressure (BP) using ABPM because it is more predictive for outcomes than daytime BP, and because nocturnal hypertension, non-dipping (ND) and reverse dipping (RD), are associated with increased cardiovascular (CV) risk.
The aim of our study was to assess the prevalence of different circadian patterns, comorbidities and risk factors according to the dipping status.
Methods: The Hungarian ABPM Registry is an ongoing, multicenter, open-label, observational study. 51428 middle-aged (55,94±15,1 years) patients (female ratio 53,8%) with known hypertension or suspected hypertension were involved in the study. Validated Meditech ABPM-06 was used. Current report analyzed 47491 ABPM, collected between 01.03.2021-30.06.2024.
Results: 72% of all patients (n=34216) were treated, 10,5% (n=4992) RDs, 42% (n=19967) NDs, 41,8% (n=19854) dippers (Ds), and 5,6% (n=2678) extreme dippers (EDs). RDs (63,39±14,24) and NDs (57,31±15,32) were older compared to Ds (53,12±14,42) and EDs (53,68±13,16) (p<0.001). RD and ND were more frequent in treated patients, compared to untreated patients (RD: 12,4% (n=4256) vs. 5,5% (n=735); ND: 43,3% (n=14816) vs. 38,8% (n=5151); (p<0,001, Cramer’s V=0,13). Obesity (RD:OR=1,27[1,19;1,37], ND:OR=1,17[1,12;1,22]), ischemic heart disease (RD:OR=3,51[3,15;3,90], ND:OR=1,85[1,69;2,01]), cerebrovascular disease (RD:OR=2,08[1,76;2,45], ND:OR=1,38[1,22;1,56]), diabetes mellitus (RD:OR=2,67[2,44;2,93], ND:OR=1,72[1,61;1,84]), chronic kidney disease (RD:OR=3,89[3,22;4,70], ND:OR=1,80[1,53;2,12]), peripheral artery disease (RD:OR=2,84[2,30;3,51], ND:OR=1,46[1,23;1,74]), retinopathy (RD:OR=2,15[1,62;2,86], ND:OR=1,42[1,14;1,77]) increased the odds of RD and ND status, compared to D status.
Conclusion: Reverse dipping and non-dipping patterns were highly prevalent in the Hungarian hypertensive population - regardless of antihypertensive treatment- which strongly associated with high CV risk.