PhD Scientific Days 2025

Poster Session III. - S: Dental Research

Bone grafting with albumin-impregnated bone allograft after odontogenic cyst removal

Name of the presenter

Rangics Anna

Institute/workplace of the presenter

Department of Dentoalveolar Surgery, Dental Training Centre, Faculty of Dentistry, Semmelweis University

Authors

Anna Rangics¹, Csaba Dobó-Nagy², Szabolcs Gyulai-Gaál¹, András Molnár³, László Simonffy¹, Gábor Dénes Répássy⁴

1: Department of Dentoalveolar Surgery, Dental Training Centre, Faculty of Dentistry, Semmelweis University
2: Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University
3: Opera Clinic, Protone Audio Kft
4: Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University

Text of the abstract

Background: Odontogenic cysts can damage surrounding bone tissues as they grow, highlighting the need for effective regenerative strategies tailored to individual pa-tients. Personalised approaches in oral surgery, such as selecting the best bone graft materials, can improve treatment outcomes. Filling the bone defect left after cyst re-moval, root resection, or extraction with a bone graft material can stabilise the weak-ened tooth and promote faster bone regeneration. This article shares our experiences with the therapeutic effects of albumin-coated bone allograft (BoneAlbumin®) placed in the bone defect following cyst removal in the oral cavity, in comparison to cases where the defect was left untreated (controls). Material and Methods: The study in-volved thirty patients who underwent the removal of maxillary odontogenic cysts. In 15 of these patients, the bone defect was filled with albumin-coated bone allograft (BoneAlbumin®, OrthoSera, Hungary), while in the control group (15 patients), the defect was left untreated. A consistent surgical protocol was adhered to throughout the study. Follow-up periapical X-rays were taken immediately after surgery, as well as at 6 and 12 weeks post-surgery, using a template. These images were used to assess the shrinkage and healing of the defect caused by the cyst. Measurements were adjusted to fixed points to account for potential distortions in the X-rays. Results: The control and study groups showed no statistically significant differences in their basic parameters. Additionally, there was no notable difference in the sizes of postoperative defects be-tween the two groups. However, statistical analysis indicated a significant difference in the changes in defect size (Δdefect size) between the groups at both 6 weeks (p<0.000001) and 12 weeks (p=0.000296). This suggests that the BoneAlbumin®-graft group experienced significantly greater changes in defect size over time. Conclusions: The use of BoneAlbumin®-graft leads to a markedly better reduction in defect size as time progresses.