PhD Scientific Days 2019

Budapest, April 25–26, 2019

Heritability of carotid and femoral atherosclerotic plaques in asymptomatic Hungarian twins

Szabó, Helga

Helga Szabó, Kata Gyulay, Zsófia Jokkel, Rebeka Zsupos, Gréta Janositz, Anita Hernyes, Viktor Bérczi, Dávid L. Tárnoki, Ádám D. Tárnoki: Department of Radiology, Semmelweis University, Budapest, Hungary

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Text of the abstract

Introduction: Carotid and femoral atherosclerotic plaques have been shown to be heritable. However, no comprehensive assessment was performed on the heritable effects of plaque volume and types which influences the management of different plaque types.

Aims: The purpose of this study was to compare the genetical and environmental background of carotid and femoral atherosclerotic plaque number, volume and types.

Method: 92 asymptomatic twins (54 monozygotic, MZ and 38 dizygotic, DZ pairs, mean age 54±13 years) from Hungary underwent comprehensive carotid and femoral 3D ultrasound examination (Samsung RS85, Arterial analysis, 15MHz probe). Plaque volume and cross-sectional area was automatically measured, and plaque types were cathegorized based on echogeneicity. Data were analyzed using descriptive statistics and raw heritability was assessed using Falconer formule.

Results: No heritability has been shown for the total number of carotid and femoral plaques (C=0.633, E=0.525) and for total carotid and femoral plaque volume (C=1.049, E=0.585). Albeit the number of carotid plaques itself was heritable (A=0.492), the volume of carotid and femoral plaques as well as the number of femoral plaques was not. The presence of calcified (conc./disc. ratio for MZ: 3/1, DZ: 0/1) and mixed carotid plaques were more concordant for MZ twins (conc./disc. ratio for MZ: 6/1, DZ: 0/5) indicating heritability.

Conclusion: The total number of carotid and femoral plaques and their volume is influenced by the environment. The different plaque types have different background: whileas the calcified and mixed carotid plaques are more influenced by genetics, the soft carotid and femoral plaques are more influenced by the environment. Our findings can influence the therapeutic management of the different atherosclerotic plaque types.

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Doctoral School: Basic and Translational Medicine
Program: Cardiovascular Disorders: Physiology and Medicine of Ischaemic Circulatory Diseases
Supervisors: Dávid László Tárnoki and Ádám Domonkos Tárnoki
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