PhD Scientific Days 2019

Budapest, April 25–26, 2019

Serum uric acid is independently associated with coronary calcification in an asymptomatic population

Kiss, Loretta

Dr Loretta Kiss
Akos Berczi
Semmelweis University Heart and Vascular Center

Language of the presentation


Text of the abstract

Introduction: Detecting early stage atherosclerosis is an important step towards cardiovascular disease prevention. Coronary artery calcium (CAC) score is a sensitive and non-invasive tool for detecting coronary atherosclerosis. Higher serum uric acid (SUA) levels are known to be associated with cardiovascular diseases. However, there is inconsistency regarding the independence of the association.
Aims: The aim of our study was to assess the association of CAC and SUA in an asymptomatic population.
Method: CAC scans of 281 participants were analysed in a voluntary screening program. A health questionnaire, physical examination and laboratory tests were also performed. Participants with a history of cardiovascular disease were excluded from the analysis.
Results: 36.3% (n=102) of the participants had no detectable CAC and 13.9% (n=39) had a CAC score of >300. SUA showed positive correlation with CAC score (0.175, p<0.01). SUA was independently associated with Ca-score>300 (OR:5.17, p=0.01) after the effects of conventional risk factors were eliminated.
Conclusion: In an asymptomatic population SUA levels were associated with calcium scores and the third SUA
tercile was an independent predictor for the presence of high-risk coronary calcification.

Data of the presenter

Doctoral School: Basic Medicine
Program: Cardiovascular Disorders,Physiology and Medicine of Ischaemic Circulatory Diseases
Supervisor: David Becker, Zsolt Szelid
E-mail address:
Preference: poster presentation