PhD Scientific Days 2021

Budapest, 7-8 July 2021

CL_I_P: Clinical Medicine I. Posters

Resting cardiac marker levels and sports adaptation

Mate Babity1, Mark Zamodics1, Reka Rakoczi1, Anna Menyhart-Hetenyi1, Albert König1, Marton Tokodi1, Erika Vargane Budai1, Balint Lakatos1, Marton Horvath1, Liliana Szabó1, Zsofia Dohy1, Csilla Czimbalmos1, Alexandra Fábián1, Attila Kovacs1, Hajnalka Vago12, Bela Merkely12, Orsolya Kiss12
1 Heart and Vascular Center, Semmelweis University, Budapest
2 Department of Sports Medicine, Semmelweis University, Budapest

Text of the abstract

After exhausting physical activity levels of cardiac markers could be elevated, but we do not have data about the relation of the resting levels and sport adaptation.
In part of sports cardiology screening, we analyzed the resting levels of hsTroponinT, CKMB, LDH and NT-proBNP and compared with a healthy sedentary non-athlete control group. All subjects underwent echocardiography examinations and cardiopulmonary exercise testing. Groups were compared with Student’s t-test or Mann-Whitney U-test; statistical analysis was processed in RStudio environment.
Results of 335 athletes (M:162, age:18.9±5.9y, training:15.8±5.9h/w) and 53 non-athletes (M:23, age:19.8±3.2y, training:2.7±2.3h/w) were compared. In athletes we measured higher CKMB (17.5±6.8 vs 12.3±3.4U/l, p<0.001) and LDH values (323.7±63.3 vs 286.0±51.1U/l, p<0.001), and lower values of NT-proBNP (27.2±29.2 vs 49 8±38.7pg/ml, p<0.001) compared to the control group, while in hsTroponinT levels (4.3±1.4 vs 5.6±6.3ng/l, p=0.33) no changes were measured. In term of the examined laboratory parameters correlation was found with maximal relative aerobe capacity (CKMB: r=0.23, p<0.001; LDH: r=0.18, p<0.001; hsTroponinT: r=0.23, p<0.001; NT-proBNP: r=-0.22, p<0.001), but no correlation was found with age. Significant correlation was found between NT-proBNP levels and echocardiographic measurements of ventricular diameters and left ventricular wall thickness (LVEDD r=-0.15, p<0.03; LVESD r=-0.18, p<0.03; RVD: r=-0.15, p<0.02; IVS: r=-0.22, p<0.001; PWD r=-0.27, p<0.001), CKMB levels correlated with left ventricular wall thickness (IVS: r=0.11, p<0.05; PWD r=0.14, p<0.02).
Based on our results, in connection with sports adaptation of the heart, the resting levels of the cardiac markers also show significant changes, these are correlated with aerobic endurance and structural sport adaptation parameters as well. Our study draws attention to the importance of different assesment of cardiac markers in athletes.
Supported by the ÚNKP-20-3-I-SE-41 New National Excellence Program, by the Thematic Excellence Programme (2020-4.1.1.-TKP2020) and by a grant from NKFIH (K 135076) of the Ministry for Innovation and Technology from the Source of the National Research, Development and Innovation fund. Development of scientific workshops of medical, health sciences and pharmaceutical educations (EFOP-3.6.3-VEKOP-16-2017-00009).

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine