PhD Scientific Days 2022

Budapest, 6-7 July 2022

Clinical Medicine I. (Poster discussion will take place in the Aula during the Coffee Break)

Renin-Angiotensin-Aldosterone System Inhibitors and Survival in Patients with Hypertension Treated with Immune Checkpoint Inhibitors

Zsofia D. Drobni, MD1,2, Olivier Michielin MD, PhD3,4, Thiago Quinaglia MD2, Daniel A. Zlotoff, MD PhD5, Leyre Zubiri, MD PhD6, Hannah K Gilman, BS2, Sama Supraja, BS2, Bela Merkely, MD1, Veronika Muller, MD7, Ryan J. Sullivan, MD6, Kerry L. Reynolds, MD6, Michael J. Pittet, PhD8, Rakesh K. Jain, PhD9, Tomas G. Neilan, MD, MPH2,5

1, Heart and Vascular Center, Semmelweis University, Budapest, Hungary
2, Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
3, Oncology Department, Precision Oncology Center, Lausanne, Switzerland
4, Oncology Department, Lausanne University Hospital, Lausanne, Switzerland
5, Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
6, Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
7, Department of Pulmonology, Semmelweis University, Budapest, Hungary
8, Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
9, Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

Text of the abstract

Introduction and Aims: Preclinical studies indicate that the concurrent use of inhibitors of the renin–angiotensin–aldosterone system (RAAS) may improve outcomes in broad groups of cancer patients. There are limited data on the association between the use of RAAS inhibitors and outcomes among patients treated with immune checkpoint inhibitors (ICIs).
Methods: We performed a retrospective study of all patients treated with an ICI in a single academic network. Of 10,903 patients, 5,910 were on any anti-hypertensive medication. Of those on anti-hypertensive therapy, 3,426 were prescribed a RAAS inhibitor during ICI treatment and 2,484 were prescribed other anti-hypertensive medications. The primary outcome was overall survival in the entire cohort and in sub-groups by cancer types.
Results: Thoracic cancer (34%) and melanoma (16%) were the most common types of cancer. Those prescribed a RAAS inhibitor were older, more frequently male, and had more cardiovascular risk factors. In a Cox proportional hazard model, the concurrent use of RAAS inhibitors was associated with better overall survival (hazard ratio (HR):0.92, [95% Confidence Interval (CI):0.85-0.99], P=.032). Patients with gastrointestinal (HR:0.82, [95% CI: 0.67-1.01], P=.057) and genitourinary cancer (HR:0.81, [95% CI:0.64-1.01], P=.067) had a non-statistically significant better overall survival.
Conclusions: In this large retrospective study, patients with hypertension who were concomitantly taking a RAAS inhibitor during ICI therapy had better overall survival. This benefit was primarily noted among patients with gastrointestinal and genitourinary cancers. Prospective randomized trials are warranted to further evaluate and specify the benefit of RAAS inhibitors in cancer patients who receive ICI therapy.