PhD Scientific Days 2023

Budapest, 22-23 June 2023

Neurosciences - Posters H

The impact of SARS-CoV-2 infection on the outcome of acute ischemic stroke-A retrospective cohort study

Tímea Tünde Takács 1 2, Ádám József Berki 1 2, Péter Pál Böjti 1 2 3, Rita Stang 1 2, Pablo Antonio Fritz-Reunes 1, Luiz Schnekenberg 4, Timo Siepmann 4 5, Alexandra Pintér 5 6, Szabolcs Szatmári 1 7, Dániel Bereczki 1 7 8, Bence Gunda 1 2
1 Semmelweis University, Department of Neurology, Budapest, Hungary.
2 Semmelweis University, "János Szentágothai" Doctoral School of Neurosciences, Budapest, Hungary.
3National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary.
4 University Hospital Carl Gustav Carus, Department of Neurology, Dresden, Germany.
5 Division of Health Care Sciences, Center for Clinical Research and Management Education, Dresden International University, Dresden, Germany.
6 Semmelweis University, Department of Family Medicine, Budapest, Hungary.
7 MTA-SE Neuroepidemiological Research Group ELKH, Budapest, Hungary.
8 European Academy of Neurology, EANcore COVID-19 Task Force, Vienna, Austria.

Text of the abstract

Acute ischemic stroke (AIS) is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection (COVID-19), but the prognosis of these patients is poorly understood. The aim of our research was to explore the impact of COVID-19 on neurological outcomes in AIS patients. A comparative retrospective cohort study was conducted in 32 consecutive AIS patients with and 51 without COVID-19 between the 1st of March 2020 and 1st of May 2021. The evaluation was based on a detailed chart review for demographic data, medical history, stroke severity, cranial and vessel imaging results, laboratory parameters, COVID-19 severity, hospitalization time, in-hospital mortality, and functional deficits at discharge (modified Rankin Scale, mRS).COVID-19 AIS patients showed tendency to worse initial neurological deficit (NIHSS 9 (3-13) vs. 4 (2-10); p = 0.06), higher rate of large vessel occlusion (LVO; 13/32 vs. 14/51; p = 0.21), had prolonged hospitalization (19.4 ± 17.7 vs. 9.7 ± 7 days; p = 0.003), had lower chance of functional independence (mRS≤2) (12/32 vs. 32/51; p = 0.02) and showed higher in-hospital mortality (10/32 vs. 6/51; p = 0.02). In COVID-19 AIS patients, LVO was more common with COVID-19 pneumonia than without (55.6% vs. 23.1%; p = 0.139).COVID-19-related AIS carries a worse prognosis. COVID-19 with pneumonia seems to be associated with a higher rate of LVO.