PhD Scientific Days 2023

Budapest, 22-23 June 2023

Clinical Medicine V.

One in Four Patients with Gastrointestinal Bleeding develops Shock or Hemodynamic Instability: A Systematic Review and Meta-analysis

Mahmoud Obeidat (1,2), Brigitta Teutsch (1,2) , Anett Rancz (1,3), Edina Tari (1,4), Katalin Márta (1,4), Dániel Sándor Veres (1,5), Nóra Hosszúfalusi (1,3), Emese Mihály (1,3), Péter Hegyi (1,2,4), Bálint Erőss(1,2,4)

1- Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
2- Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
3- Department of Internal Medicine and Hematology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
4- Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary
5- Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary

Text of the abstract

Hemodynamic instability and shock are associated with untoward outcomes in gastrointestinal bleeding. However, there are no studies in the existing literature on the proportion of patients who developed these outcomes after gastrointestinal bleeding.

We aimed to meta-analyze the available data to determine these proportions in different bleeding sources.

The protocol was registered on PROSPERO in advance (CRD42021283258). A systematic search was performed in three databases (PubMed, Embase, and CENTRAL) on 14th October 2021. Pooled proportions with 95% confidence intervals (CI) were calculated with a random-effects model. A subgroup analysis was carried out based on the time of assessment (on admission or during hospital stay). Heterogeneity was assessed by Higgins and Thompson’s I². The Joanna Briggs Institute Prevalence Critical Appraisal Tool was used for the risk of bias assessment.

We identified 11,589 records, of which 220 studies were eligible for data extraction. The overall proportion of shock and hemodynamic instability in general gastrointestinal bleeding patients was 0.25 (CI: 0.17–0.36). In non-variceal bleeding, the proportion was 0.22 (CI: 0.14–0.31), whereas it was 0.25 (CI: 0.19–0.32) in variceal bleeding. The proportion of patients with colonic diverticular bleeding who developed shock or hemodynamic instability was 0.12 (CI: 0.06–0.22). The risk of bias was low, and heterogeneity was high in all analyses.

One in five, one in four, and one in eight patients develop shock or hemodynamic instability on admission or during the hospital stay in the case of non-variceal, variceal, and colonic diverticular bleeding, respectively.