PhD Scientific Days 2023

Budapest, 22-23 June 2023

Clinical Medicine - Posters I

The risk factors of acute pancreatitis progression into recurrent acute pancreatitis and chronic pancreatitis. A systematic review and meta – analysis.

authors: Endre - Botond Gagyi1,2, Mahmoud Obeidat1,3, Edina Tari1,6, Szilárd Váncsa1,3,6, Dániel Sándor Veres1,4, Banovcin Peter5, Péter Jenő Hegyi1,3,6, Péter Hegyi1,3,6 , Bálint Erőss1,3,6
1. Center for Translational Medicine, Semmelweis University, Budapest, Hungary
2. Selye János Doctoral College for Advanced Studies, Semmelweis University, Budapest, Hungary
3. Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
4. Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary
5. Gastroenterology Clinic, University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
6. Division of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary

Text of the abstract

Aim: This systematic review and meta-analysis aimed to identify risk factors associated with this progression.
Methods: The protocol was registered on PROSPERO (CRD42022368931). A comprehensive search was conducted in three (Medline, Embase, Cochrane) databases on October 25th, 2022. Articles reporting AP – RAP or RAP – CP patient groups comparisons and risk factors associated with AP progression into RAP or CP were included. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using the random effects model. Heterogeneity was evaluated using the I² statistic. The risk of bias assessment was performed using the Quality in Prognostic Studies (QUIPS) tool.
Results: A total of 71 articles were included in the meta–analysis, and several risk factors were identified for the progression of AP into RAP and CP. We found the following risk factors of AP recurrence: younger age, male gender, smoking, alcoholic etiology, hypertriglyceridemia, diabetes mellitus, pseudocyst, etc. The pooled OR for the male gender was 1.45 (95% CI: 1.29-1.64, I²=24%), for smoking was 1.45 (95% CI: 1.16-1.81, I²=62%), for alcoholic etiology was 1.76 (95% CI: 1.38-2.25, I²=81%), for hypertriglyceridemia was 2.45 (95% CI: 2.07-2.90, I²=9%), for diabetes mellitus was 1.49 (95% CI: 1.24-1.80, I²=0%), for pseudocyst was 2.19 (95% CI: 1.52-3.15, I²=0%). We also found risk factors of RAP progression into CP, which were the following: male gender, alcoholic etiology, alcohol consumption, smoking, etc. The risk of bias was moderate in the majority of the included studies.
Conclusion: Our study identified multiple modifiable risk factors which can be treated to prevent the progression of pancreatitis.
Funding: None to declare.